The US is set to spend $113m on digital economy, energy and infrastructure in Asia, a move seen as an attempt to counter China’s growing influence.
US Secretary of State Mike Pompeo made the pledge while outlining the "Indo-Pacific" economic strategy in a speech to business leaders in Washington.
He said the US believed in "strategic partnerships not strategic dependency".
The announcement comes at a time when the US and China are butting heads in a tit-for-tat trade war.
The Trump administration strategy to build influence with a regional grouping identified as the "Indo-Pacific", which includes the US west coast, South East Asian nations and India, is seen as a response to China’s Belt and Road initiative.
That has seen Beijing sink billions into the rebuilding of ports, roads and railways across Asia as part of China’s effort to increase its political and strategic influence in Asia and beyond.
Mr Pompeo made pointed reference to this in his speech to the US Chamber of Commerce "The United States of America does not invest for political influence, but rather practices partnership economics," he said.
"These funds represent just a down payment on a new era in US economic commitment to peace and prosperity in the Indo-Pacific region."
The investment will be seen as a drop in the ocean compared with the vast funds China has sunk into the Belt and Road initiative, but analysts say it is a sign that the US intends to boost its engagement with Asian economies.
The US has carried out an increasingly protectionist economic agenda since US President Donald Trump took office in 2016, setting the tone early on when he pulled out of the Trans Pacific Partnership deal last year.
It also slapped tariffs on $34bn of Chinese goods earlier this month and has accused China of intellectual copyright theft.
